Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody

Academic Article

Abstract

  • THE production of antiplatelet antibodies and removal of IgG-coated platelets by the mononuclear phagocyte system play an important part in the pathogenesis of immune thrombocytopenic purpura. The coating of platelets with immunoglobulin results in their removal in the spleen and liver, presumably by receptors for the Fc fragment of IgG (Fcγ).1,2 Prolongation of Fcγ-receptor-mediated clearance of opsonized red cells after splenectomy1,3 and infusions of high doses of intravenous gamma globulin,4,5 in conjunction with favorable clinical responses to these therapies, support this hypothesis. Some patients, however, respond to neither of these treatments nor to other, less specific forms of immunosuppression, such. © 1986, Massachusetts Medical Society. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Clarkson SB; Bussel JB; Kimberly RP; Valinsky JE; Nachman RL; Unkeless JC
  • Start Page

  • 1236
  • End Page

  • 1239
  • Volume

  • 314
  • Issue

  • 19