Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor

Academic Article

Abstract

  • The binding of multivalent immunoglobulin G complexes to Fc receptors (FcγRs) on macrophages activates multiple immune functions. A murine macrophage cell line, but not a fibroblast cell line, that was transfected with human FcγRIIA mediated phagocytosis and an intracellular Ca2+ concentration ([Ca2+]i) flux upon cross-linking of human FcγRIIA. Transfected macrophages that expressed a truncated receptor lacking 17 carboxy-terminal amino acids phagocytosed small antibody complexes. However, only wild-type transfectants phagocytosed labeled erythrocytes and fluxed [Ca2+]i. Thus, the cytoplasmic domain of human FcγRIIA contains distinct functional regions.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Odin JA; Edberg JC; Painter CJ; Kimberly RP; Unkeless JC
  • Start Page

  • 1785
  • End Page

  • 1788
  • Volume

  • 254
  • Issue

  • 5039