Patient-reported outcomes in chronic gout: a report from OMERACT 10.

Academic Article

Abstract

  • OBJECTIVE: To summarize the endorsement of measures of patient-reported outcome (PRO) domains in chronic gout at the 2010 Outcome Measures in Rheumatology Meeting (OMERACT 10). METHODS: During the OMERACT 10 gout workshop, validation data were presented for key PRO domains including pain [pain by visual analog scale (VAS)], patient global (patient global VAS), activity limitation [Health Assessment Questionnaire-Disability Index (HAQ-DI)], and a disease-specific measure, the Gout Assessment Questionnaire version 2.0 (GAQ v2.0). Data were presented on all 3 aspects of the OMERACT filters of truth, discrimination, and feasibility. One PRO, health-related quality of life measurement with the Medical Outcomes Study Short-form 36 (SF-36), was previously endorsed at OMERACT 9. RESULTS: One measure for each of the 3 PRO of pain, patient global, and activity limitation was endorsed by > 70% of the OMERACT delegates to have appropriate validation data. Specifically, pain measurement by VAS was endorsed by 85%, patient global assessment by VAS by 73%, and activity limitation by HAQ-DI by 71%. GAQ v2.0 received 30% vote and was not endorsed due to several concerns including low internal consistency and lack of familiarity with the measure. More validation studies are needed for this measure. CONCLUSION: With the endorsement of one measure each for pain, patient global, SF-36, and activity limitation, all 4 PRO for chronic gout have been endorsed. Future validation studies are needed for the disease-specific measure, GAQ v2.0. Validation for PRO for acute gout will be the focus of the next validation exercise for the OMERACT gout group.
  • Published In

    Keywords

  • Chronic Disease, Disability Evaluation, Feasibility Studies, Gout, Gout Suppressants, Humans, Outcome Assessment (Health Care), Pain Measurement, Reproducibility of Results, Self Report, Surveys and Questionnaires, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Singh JA; Taylor WJ; Simon LS; Khanna PP; Stamp LK; McQueen FM; Neogi T; Gaffo AL; Becker MA; MacDonald PA
  • Start Page

  • 1452
  • End Page

  • 1457
  • Volume

  • 38
  • Issue

  • 7