Tophus measurement as an outcome measure for clinical trials of chronic gout: progress and research priorities.

Academic Article

Abstract

  • Despite the recognition that tophus regression is an important outcome measure in clinical trials of chronic gout, there is no agreed upon method of tophus measurement. A number of methods have been used in clinical trials of chronic gout, from simple physical measurement techniques to more complex advanced imaging methods. This article summarizes methods of tophus measurement and discusses their properties. Physical measurement using Vernier calipers meets most aspects of the Outcome Measures in Rheumatology (OMERACT) filter. Rigorous testing of the complex methods, particularly with respect to reliability and sensitivity to change, is needed to determine the appropriate use of these methods. Further information is also required regarding which method of physical measurement is best for use in future clinical trials. The need to develop and test a patient-reported outcome measure of tophus burden is also highlighted.
  • Published In

    Keywords

  • Chronic Disease, Clinical Trials as Topic, Gout, Gout Suppressants, Humans, Joints, Outcome Assessment (Health Care), Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome, Ultrasonography
  • Digital Object Identifier (doi)

    Authorlist

  • Dalbeth N; McQueen FM; Singh JA; MacDonald PA; Edwards NL; Schumacher HR; Simon LS; Stamp LK; Neogi T; Gaffo AL
  • Start Page

  • 1458
  • End Page

  • 1461
  • Volume

  • 38
  • Issue

  • 7