Comorbidities in patients with crystal diseases and hyperuricemia.

Academic Article


  • Crystal arthropathies are among the most common causes of painful inflammatory arthritis. Gout, the most common example, has been associated with cardiovascular and renal disease. In recent years, evidence for these associations and those involving other comorbidities, such as the metabolic syndrome, have emerged, and the importance of asymptomatic hyperuricemia has been established. In this review, an update on evidence, both experimental and clinical, is presented, and associations between hyperuricemia, gout, and several comorbidities are described. Causality regarding calcium pyrophosphate arthropathy and associated comorbidities is also reviewed.
  • Keywords

  • Calcium pyrophosphate arthropathy, Cardiovascular disease, Comorbidities, Crystal arthropathies, Gout, Hyperuricemia, Metabolic syndrome, Renal disease, Acute Kidney Injury, Cardiovascular Diseases, Cerebrovascular Disorders, Chondrocalcinosis, Comorbidity, Coronary Disease, Diabetes Mellitus, Gout, Heart Failure, Humans, Hypertension, Hyperuricemia, Metabolic Syndrome, Neurodegenerative Diseases, Osteoarthritis, Renal Insufficiency, Chronic
  • Digital Object Identifier (doi)

    Author List

  • Sattui SE; Singh JA; Gaffo AL
  • Start Page

  • 251
  • End Page

  • 278
  • Volume

  • 40
  • Issue

  • 2