Ethnic variations in the prevalence of metabolic bone disease among HIV-positive patients with lipodystrophy.

Academic Article

Abstract

  • A high prevalence of metabolic bone disease and osteonecrosis among HIV+ patients on highly active antiretroviral therapy (HAART) has been reported in predominantly white cohorts. We examined bone health in an ethnically diverse cohort of 23 African-Americans and 21 non-African-Americans who were mean (standard deviation) age 45 (7) years old, 66% male, and on HAART for 34 (28) months. Non-African-Americans were more likely to have osteopenia or osteoporosis (59%) compared to African-Americans (26%) (p = 0.09). The prevalence of vitamin D insufficiency (< 34 ng/ml) and elevated i-PTH (>65 pg/ml) was 79% and 20%, respectively. Higher mean urinary N-telopeptide levels were found in non-African-Americans [58 (34) nmol BCE/mmol] compared to African-Americans [41 (18) nmol BCE/mmol] (p = 0.09). Magnetic resonance imaging identified one African-American subject (3%) with bilateral asymptomatic hip osteonecrosis. Our findings suggest that the burden of metabolic bone disease in HIV+ patients with HAART-associated lipodystrophy may be greater in whites than in African-Americans. Studies to examine ethnic variations in bone metabolism are necessary to devise optimal interventions.
  • Published In

    Keywords

  • Absorptiometry, Photon, Adolescent, Adult, Antiretroviral Therapy, Highly Active, Bone Density, Bone Diseases, Metabolic, Collagen Type I, Ethnic Groups, Female, HIV Infections, Humans, Lipodystrophy, Male, Middle Aged, Peptides, Prevalence
  • Digital Object Identifier (doi)

    Pubmed Id

  • 15781169
  • Author List

  • Curtis JR; Smith B; Weaver M; Landers K; Lopez-Ben R; Raper JL; Saag M; Venkataraman R; Saag KG
  • Start Page

  • 125
  • End Page

  • 131
  • Volume

  • 22
  • Issue

  • 2