Progressive joint destruction in a human immunodeficiency virus‐infected patient with rheumatoid arthritis

Academic Article


  • This article reports the case of a 63‐year‐old patient with rheumatoid arthritis (RA) whose symptoms of RA improved after the occurrence of a secondary human immunodeficiency virus (HIV) infection; however, the HIV infection did not affect the histologic parameters of joint destruction to the same extent as it did the clinical symptoms. Histologic and immunohistologic joint examinations of this patient revealed an ongoing production of cartilage‐ and bone‐degrading enzymes by macrophages and fibroblasts, without the presence of T cells. These findings demonstrate that progressive joint destruction in RA can occur in the absence of T cells. Moreover, our results support the hypothesis that both T cell‐dependent and T cell‐independent pathways play a significant role in the pathogenesis of RA. Copyright © 1995 American College of Rheumatology
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    Digital Object Identifier (doi)

    Author List

  • Müller‐Ladner U; Kriegsmann J; Gay RE; Koopman WJ; Gay S; Chatham WW
  • Start Page

  • 1328
  • End Page

  • 1332
  • Volume

  • 38
  • Issue

  • 9