A novel single nucleotide polymorphism and five probable haplotypes in the 5' flanking region of the IL-6 gene in African-Americans.

Academic Article

Abstract

  • In order to identify novel single nucleotide polymorphisms (SNPs), we sequenced a 940 bp region of the 5' flanking region of the IL-6 gene in 63 normal African-Americans. We identified a biallelic (G/C) SNP at position -573 relative to the transcription start site (-573C allele frequency 0.095). This SNP, together with SNPs at -598 and -174, allows identification of five probable haplotypes. Haplotypes containing the -174C allele, which has been associated with lower plasma IL-6 levels, were uncommon (4%). These haplotypes may influence IL-6 gene transcription and thus may contribute to racial differences in the prevalence of inflammatory diseases.
  • Published In

  • Genes and Immunity  Journal
  • Keywords

  • African Continental Ancestry Group, Haplotypes, Humans, Interleukin-6, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, United States
  • Digital Object Identifier (doi)

    Author List

  • Osiri M; McNicholl J; Moreland LW; Bridges SL
  • Start Page

  • 166
  • End Page

  • 167
  • Volume

  • 1
  • Issue

  • 2