Genetic influences on rheumatoid arthritis in African Americans.

Academic Article

Abstract

  • Rheumatoid arthritis is a common autoimmune disease characterized by inflammation of the synovial membrane of diarthrodial joints, which often leads to joint damage and disability. There are known associations between major histocompatibility complex class II alleles and susceptibility to rheumatoid arthritis and its severity in Caucasians. African Americans, an admixed population in the United States, has been underrepresented in genetic studies of the susceptibility and severity of rheumatoid arthritis. With the advent of biologic agents, which target specific molecules of the immune system (e.g., tumor necrosis factor, interleukin-1), biologic markers of treatment response in Caucasians and in African Americans would be clinically useful.
  • Published In

    Keywords

  • African Continental Ancestry Group, Alleles, Antirheumatic Agents, Arthritis, Rheumatoid, European Continental Ancestry Group, Genes, MHC Class II, Genetic Markers, Genetics, Population, Humans, Methotrexate, Receptors, Tumor Necrosis Factor, Tumor Necrosis Factor-alpha, United States
  • Digital Object Identifier (doi)

    Author List

  • Hughes LB; Moreland LW; Bridges SL
  • Start Page

  • 15
  • End Page

  • 26
  • Volume

  • 26
  • Issue

  • 1-3