Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

Academic Article

Abstract

  • T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC) formation and long-lived antibody responses. However, the cellular and molecular mechanisms that control Tfh cell differentiation in vivo are incompletely understood. Here we show that interleukin-2 (IL-2) administration impaired influenza-specific GCs, long-lived IgG responses, and Tfh cells. IL-2 did not directly inhibit GC formation, but instead suppressed the differentiation of Tfh cells, thereby hindering the maintenance of influenza-specific GC B cells. Our data demonstrate that IL-2 is a critical factor that regulates successful Tfh and B cell responses in vivo and regulates Tfh cell development. © 2012 Elsevier Inc.
  • Digital Object Identifier (doi)

    Author List

  • Ballesteros-Tato A; León B; Graf BA; Moquin A; Adams PS; Lund FE; Randall TD
  • Start Page

  • 847
  • End Page

  • 856
  • Volume

  • 36
  • Issue

  • 5