Regulation of T H2 development by CXCR5 + dendritic cells and lymphotoxin-expressing B cells

Academic Article

Abstract

  • Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7 + naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4 + T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T H2 cells), which suggests that T H2 differentiation can initiate outside the T cell zone. © 2012 Nature America, Inc. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • León B; Ballesteros-Tato A; Browning JL; Dunn R; Randall TD; Lund FE
  • Start Page

  • 681
  • End Page

  • 690
  • Volume

  • 13
  • Issue

  • 7