FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

Academic Article

Abstract

  • Here, we test the role of FoxP3+ regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor-progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation. © 2014 Macmillan Publishers Limited. All rights reserved.
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    Author List

  • León B; Bradley JE; Lund FE; Randall TD; Ballesteros-Tato A
  • Volume

  • 5