Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)

Academic Article

Abstract

  • Background: The mechanistic role of peroxisome proliferator-activated receptor γ (PPARγ) in chronic obstructive pulmonary disease (COPD) is poorly understood. Results: COPD and cigarette smoke exposure down-regulated PPARγ and produced inflammation that PPARγ agonists reversed through multiple pathways. Conclusion: PPARγ plays a pivotal role in COPD. Significance: PPARγ agonists may be the first effective treatment for COPD. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Lakshmi SP; Reddy AT; Zhang Y; Sciurba FC; Mallampalli RK; Duncan SR; Reddy RC
  • Start Page

  • 6383
  • End Page

  • 6393
  • Volume

  • 289
  • Issue

  • 10