ETA activation mediates angiotensin II-induced infiltration of renal cortical T cells

Academic Article

Abstract

  • T cells and endothelin (ET-1) both contribute to angiotensin II (AngII)-dependent hypertension. To determine whether ET-1, via the ET A receptor, facilitates T cell infiltration in the kidney during AngII-dependent hypertension, we measured T cell infiltration in response to four different treatments: saline, AngII infusion, AngII infusion with an ETA receptor antagonist, or AngII infusion with triple- antihypertensive therapy. After 14 days, AngII increased both BP and the numbers of CD3+and proliferating cells in the kidney. Mice treated concomitantly with the ETAreceptor antagonist had lower BP and fewer CD3+ and proliferating cells in the renal cortex. Mice treated with triple therapy had similar reductions in BP but no change in renal cortical CD3+ cells compared with kidneys from AngII-infused hypertensive mice. In the outer medulla, both the ETA receptor antagonist and triple therapy reduced the number of CD3+ cells and macrophages. Taken together, these data suggest that ETA receptor activation in AngII-mediated hypertension increases CD3+ cells and proliferation in the renal cortex independent of changes in BP, but changes in the number of inflammatory cells in the renal medulla are BP dependent. Copyright © 2011 by the American Society of Nephrology.
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  • 2187
  • End Page

  • 2192
  • Volume

  • 22