Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.

Academic Article

Abstract

  • Gene mutations in WNK4 kinase cause a genetic form of hypertension by affecting multiple ion transport pathways through different mechanisms. Cai et al. report that the inhibitory effect of WNK4 on the thiazide-sensitive sodium-chloride cotransporter occurs through the lysosomal degradation pathway in mammalian cells.
  • Published In

    Keywords

  • Animals, Carrier Proteins, Humans, Hypertension, Ion Transport, Kidney Tubules, Distal, Lysosomes, Mutation, Protein-Serine-Threonine Kinases, Pseudohypoaldosteronism, Signal Transduction, Sodium Chloride Symporters
  • Digital Object Identifier (doi)

    Authorlist

  • Peng J-B; Bell PD
  • Start Page

  • 2116
  • End Page

  • 2118
  • Volume

  • 69
  • Issue

  • 12