Association of CD20+ infiltrates with poorer clinical outcomes in acute cellular rejection of renal allografts

Academic Article

Abstract

  • We undertook a study to ascertain the relationship between the presence of CD20-positive B-lymphocytes in renal allografts undergoing acute cellular rejection and graft survival. We identified 27 patients transplanted between January 1, 1998 and December 31, 2001, with biopsy-proven Banff 1-A or Banff 1-B rejection in the first year after transplantation, and stained the specimens for CD20 and C4d. At least 4 years of follow-up data were available for each patient studied. Six patients had CD20-positive B-cell clusters in the interstitium, and 21 patients were negative for CD20 infiltrates. The CD20-positive group was significantly more likely to have steroid-resistant rejection and reduced graft survival compared to CD20-negative controls. This study supports prospective identification of CD20-positive B-cell clusters in biopsy-proven rejection and offers a therapeutic rationale for a trial of monoclonal anti-CD20 antibody in such patients. Copyright © Blackwell Munksgaard 2005.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hippen BE; DeMattos A; Cook WJ; Kew CE; Gaston RS
  • Start Page

  • 2248
  • End Page

  • 2252
  • Volume

  • 5
  • Issue

  • 9