Combined effects of adrenalectomy and noise exposure on compound action potentials, endocochlear potentials and endolymphatic potassium concentrations

Academic Article


  • The effects of removal of endogenous corticosteroids via bilateral adrenalectomy in combination with noise exposure (30 min at 100 dB) were determined by recording compound action potentials (CAP) and endocochlear potentials EP), and by measuring potassium concentrations (Ke+) within the endolymph. Thirty-eight Long-Evans rats were divided into groups according to experimental treatments: adrenalectomy (ADX) or non-ADX and noise exposure or non-noise exposure. CAP thresholds, EP and Ke+ values were subjected to repeated-measures analysis of variance with group and time as factors classifying the measurements. Noise exposure resulted in significant elevations of CAP thresholds in both the ADX and non-ADX animals, but had no effect on either EP or endolymphatic Ke+. Recovery was noted during all post-exposure measurement periods and was significantly faster to ADX animals. EP and K3+ did not change during or after noise exposure. ADX animals showed a non-significant reduction of EP and a statistically significant increase of Ke+ during all measurement periods as compared to non-ADX animals. © 1995.
  • Authors

    Published In

  • Hearing Research  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8113435
  • Author List

  • Ma YL; Gerhardt KJ; Curtis LM; Rybak LP; Whitworth C; Rarey KE
  • Start Page

  • 79
  • End Page

  • 86
  • Volume

  • 91
  • Issue

  • 1-2