Receptors for glucocorticoids in the human inner ear

Academic Article


  • Glucocorticoid receptors were detected in the human inner ear. The highest concentration of glucocorticoid receptor protein was measured by enzyme-linked immunosorbent assay in the spiral ligament tissues; the lowest concentration of glucocorticoid receptors was measured in the macula of the saccule. The demonstration of the presence of glucocorticoid receptors in human inner ear tissues provides a basis to consider the direct effects of glucocorticoid action on select inner ear cells, rather than assuming a systemic antiinflammatory or immunosuppressive effect during the therapeutic treatment of patients with given inner ear disorders.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 15870519
  • Author List

  • Rarey KE; Curtis LM
  • Start Page

  • 38
  • End Page

  • 41
  • Volume

  • 115
  • Issue

  • 1