Intravascular catheter exchange and duration of candidemia. NIAID Mycoses Study Group and the Candidemia Study Group.

Academic Article


  • During a comparative trial of amphotericin B vs. fluconazole for treatment of candidemia in nonneutropenic patients, data on the management of intravascular catheters were collected. Complete records were available for 91% of the 206 study patients. For the subset of patients with a catheter in place at the time of their first positive blood culture, removal and replacement of all intravascular catheters without exchange over a guidewire from a preexisting line on or before the first day the study drug was administered were associated with a reduction in the subsequent mean duration (+/- SE) of candidemia, from 5.6 +/ -0.8 days to 2.6 +/- 0.5 days (P < .001).
  • Published In


  • Amphotericin B, Antifungal Agents, Candidiasis, Catheterization, Fluconazole, Humans, Time Factors
  • Digital Object Identifier (doi)

    Author List

  • Rex JH; Bennett JE; Sugar AM; Pappas PG; Serody J; Edwards JE; Washburn RG
  • Start Page

  • 994
  • End Page

  • 996
  • Volume

  • 21
  • Issue

  • 4