Immunologic and virologic consequences of temporary antiretroviral treatment interruption in clinical practice.

Academic Article

Abstract

  • To determine the long-term immunologic and virologic effects of antiretroviral treatment interruptions, a retrospective analysis of an ongoing observational database was performed at a university HIV clinic. All patients who began highly active antiretroviral therapy (HAART) after January 1, 1996 and (1) were HAART experienced for >/=90 days, (2) had a treatment interruption (TI) for >/=30 days, (3) resumed HAART for >/=30 days, and (4) had CD4(+) cell counts performed pre- and post-TI were included. Main outcome measures included the following: Immunologic success was defined as a post-TI CD4(+) cell count >90% of the pre-TI CD4(+) cell count (post-TI/pre-TI, >90%). Virologic success was defined as a post-TI viral load (VL) less or equal to twice the pre-TI VL (post-TI/pre-TI,
  • Published In

    Keywords

  • Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Male, Viral Load
  • Digital Object Identifier (doi)

    Author List

  • Chen RY; Westfall AO; Raper JL; Cloud GA; Chatham AK; Acosta EP; Pham SV; Tolson JM; Heudebert GR; Saag MS
  • Start Page

  • 909
  • End Page

  • 916
  • Volume

  • 18
  • Issue

  • 13