Physical activity and health outcomes among HIV-infected men who have sex with men: A longitudinal mediational analysis

Academic Article

Abstract

  • Background: Low physical activity is associated with depression, which may, in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence. Purpose: The purpose of this study was to examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men. Methods: The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care. Results: Across time, depression mediated the relationship between physical inactivity and ART non-adherence (γ = 0.075) and the relationship between physical inactivity and viral load (γ = 0.05). ART non-adherence mediated the relationship between depression and viral load (γ = 0.002) and the relationship between physical inactivity and viral load (γ = 0.009). Conclusions: Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load. © 2013 The Society of Behavioral Medicine.
  • Digital Object Identifier (doi)

    Author List

  • Blashill AJ; Mayer KH; Crane H; Magidson JF; Grasso C; Mathews WC; Saag MS; Safren SA
  • Start Page

  • 149
  • End Page

  • 156
  • Volume

  • 46
  • Issue

  • 2