Comparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men

Academic Article

Abstract

  • Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 μg/ml. Cefoperazone (1.0 g) and spectinomycin (2.0 g) are comparable for the therapy of anogenital gonorrhea in men.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hook EW; Judson FN; Verdon MS; Ehret JM; Handsfield HH
  • Start Page

  • 619
  • End Page

  • 621
  • Volume

  • 30
  • Issue

  • 4