The efficacy of single dose enoxacin, 400 mg was compared to ceftriaxone, 250 mg IM for therapy of uncomplicated gonor rhea in 152 evaluable patients attending sexually transmitted disease clinics in Baltimore, Indianapolis and Seattle. Anogen ital gonorrhea was cured in 75 (99%) of 76 patients treated with enoxacin and 73 (97%) of 75 patients treated with cef triaxone. Three of three patients with pharyngeal gonorrhea were not cured by enoxacin while all three ceftriaxone treated cases of pharyngeal gonorrhea were cured. All cases of ano genital gonorrhea caused by beta-Iactamase producing Neis seria gonorrheae (11 patients), gonococci with high-level, plas mid-mediated tetracycline resistance (11 patients), or gono cocci with chromosomally mediated penicillin resistance (22 patients) were cured. The IC90 for enoxacin of N. gonorrhoeae isolated in this study was 0.06 μg/ml. Enoxacin appears to be a well tolerated, efficacious alternative to currently recom mended therapy for patients with uncomplicated, anogenital gonorrhea including cases potentially caused by antibiotic re sistant N. gonorrhoeae. © 1989 American Sexually Transmitted Diseases Association.