Nora FROMDR. MERLE A. SANDE - Whileinfectious diseases clinicians have beenschooled in syphilology for generations, new aspects of syphilis continue to appear. Such is the casein HIV-infected individuals, inwhomthe clinical, diagnostic, and therapeutic implications are quite confusing. Dr. Edward W. Hook III, associate professor of medicine at The Johns Hopkins University Schoolof Medicine, has been one of the front-runners in examining and describing new aspects of this age-old infection. In this AIDS Commentary he discusses the critical clinical questions relevant to syphilis in persons with HIV infection. © 1989 by The University of Chicago.