Immunoglobulin-specific responses to chlamydia elementary bodies in individuals with and at risk for genital chlamydial infection

Academic Article

Abstract

  • Renewed interest in chlamydia vaccination has revealed the need for a greater understanding of the seroprevalence of chlamydial infection in US populations. We used a Chlamydia trachomatis elementary body (EB)-based enzyme-linked immunosorbent assay to define the characteristics of the humoral immune response and to determine seroprevalence. Two groups were analyzed: one consisting of patients with current, laboratory confirmed, genital chlamydial infection (n = 98) and one group of individuals whose chlamydia infection history was unknown (n = 367). C. trachomatis seropositivity was detected in 90% of the infected group and in 31% of the chlamydia-unknown group. IgG1 and IgG3 comprised the predominant anti-Chlamydia serum antibody responses. Serum IgA1 responses were variably positive, and individuals were rarely positive for anti-chlamydia IgG2, IgG4 or IgA2. The magnitude of the IgG1 and IgG3 responses was greatest in female and African American individuals and was sustained for at least 6 months. Antibody responses were not serovar restricted or confounded by Chlamydia pneumoniae cross-reactivity. © 2012 The Author.
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    Digital Object Identifier (doi)

    Author List

  • Geisler WM; Morrison SG; Doemland ML; Iqbal SM; Su J; Mancevski A; Hook EW; Morrison RP
  • Start Page

  • 1836
  • End Page

  • 1843
  • Volume

  • 206
  • Issue

  • 12