Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer

Academic Article

Abstract

  • A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5′-position have been synthesised. These compounds bear a 5′-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding α-linker nucleosides with L-xylose and L-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP. Copyright © Taylor & Francis, Inc.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18182444
  • Author List

  • Silamkoti AV; Allan PW; Hassan AEA; Fowler AT; Sorscher EJ; Parker WB; Secrist JA
  • Start Page

  • 881
  • End Page

  • 885
  • Volume

  • 24
  • Issue

  • 5-7