Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer.

Academic Article

Abstract

  • A novel series of 6-methylpurine nucleoside derivatives with substitutions at 5-position have been synthesised These compounds bear a 5'-heterocycle such as triazole or a imidazole with a two carbon chain, and an ether, thio ether or amine. To extend the SAR study of 2-fluoroadenine and 6-methyl purine nucleosides, their corresponding alpha-linker nucleosides with L-xylose and L-lyxose were also synthesized. All of these compounds have been evaluated for their substrate activity with E. coli PNP.
  • Published In

    Keywords

  • Adenine, Antineoplastic Agents, Carbon, Escherichia coli, Genetic Therapy, Humans, Models, Chemical, Mutation, Neoplasms, Nucleosides, Prodrugs, Purine Nucleosides, Purine-Nucleoside Phosphorylase, Purines, Substrate Specificity, Xylose
  • Pubmed Id

  • 18182444
  • Author List

  • Silamkoti AV; Allan PW; Hassan AEA; Fowler AT; Sorscher EJ; Parker WB; Secrist JA
  • Start Page

  • 881
  • End Page

  • 885
  • Volume

  • 24
  • Issue

  • 5-7