Viral dynamics in human immunodeficiency virus type 1 infection.

Academic Article

Abstract

  • The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life approximately 2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.
  • Published In

  • Nature  Journal
  • Keywords

  • Antiviral Agents, Base Sequence, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cell Survival, DNA, Viral, Drug Resistance, Microbial, Genotype, HIV Infections, HIV Protease Inhibitors, HIV Reverse Transcriptase, HIV-1, Humans, Leukocytes, Mononuclear, Molecular Sequence Data, Mutation, Phenotype, RNA, Viral, RNA-Directed DNA Polymerase, Reverse Transcriptase Inhibitors, Viremia, Virus Replication
  • Digital Object Identifier (doi)

    Author List

  • Wei X; Ghosh SK; Taylor ME; Johnson VA; Emini EA; Deutsch P; Lifson JD; Bonhoeffer S; Nowak MA; Hahn BH
  • Start Page

  • 117
  • End Page

  • 122
  • Volume

  • 373
  • Issue

  • 6510