Emerging targets for treating sulfur mustard–induced injuries

Academic Article

Abstract

  • © 2016 New York Academy of Sciences. Sulfur mustard (SM; bis-(2-chlororethyl) sulfide) is a highly reactive, potent warfare agent that has recently reemerged as a major threat to military and civilians. Exposure to SM is often fatal, primarily due to pulmonary injuries and complications caused by its inhalation. Profound inflammation, hypercoagulation, and oxidative stress are the hallmarks that define SM-induced pulmonary toxicities. Despite advances, effective therapies are still limited. This current review focuses on inflammatory and coagulation pathways that influence the airway pathophysiology of SM poisoning and highlights the complexity of developing an effective therapeutic target.
  • Digital Object Identifier (doi)

    Author List

  • Ahmad S; Ahmad A
  • Start Page

  • 123
  • End Page

  • 131
  • Volume

  • 1374
  • Issue

  • 1