Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

Academic Article

Abstract

  • THE depletion of CD4 T cells in AIDS is correlated with high turnover of the human immunodeficiency virus HIV- and associated with apoptosis . The molecular mechanism of apoptosis in HIV infection, however, is largely unknown. T-cell apoptosis might be affected by viral proteins such as HIV-1 Tat and gp120 (refs 10, 11). T-cell-receptor (TCR)-induced apoptosis was recently shown to involve the CD95 (APO-1/Fas) receptor . We show here that HIV-1 Tat strongly sensitizes TCR- and CD4(gpl20)-induced apoptosis by upregulation of CD95 ligand expression. Concentrations of Tat found to be effective in cultures of HIV-1-infected cells were also observed in sera from HIV-1-infected individuals. Taken together, our results indicate that HIV-1 Tat and gp!20 accelerate CD95-mediated, activation-induced T-cell apoptosis, a mechanism that may contribute to CD4 T-cell depletion in AIDS. © 1995 Nature Publishing Group. + 1,2 3-5 6-9 12 + 5,13,14
  • Published In

  • Nature  Journal
  • Digital Object Identifier (doi)

    Author List

  • Westendorp MO; Frank R; Ochsenbauer C; Stricker K; Dhein J; Walczak H; Debating KM; Krammer PH
  • Start Page

  • 497
  • End Page

  • 500
  • Volume

  • 375
  • Issue

  • 6531