Transfer hydrogenation; a convenient method for removal of some commonly used protecting groups in peptide synthesis

Academic Article

Abstract

  • N-Benzyloxycarbonyl and benzyl ester groups in peptidescan be conveniently removed by transfer hydrogenation with cyclohexene and 10% palladium-carbon catalyst. If freshly prepared palladium black catalyst is used, other commonly used protecting groups like Nτ-benzyl (histidine), benzyl ether (tyrosine, serine), and nitro (arginine) can also be removed much more rapidly than in the case of the usually employed catalytic hydrogenation.
  • Author List

  • Anantharamaiah GM; Sivanandaiah KM
  • Start Page

  • 490
  • End Page

  • 491
  • Issue

  • 5