Structure and function of apolipoprotein A-I and high-density lipoprotein.

Academic Article

Abstract

  • Structural biology and molecular modeling have provided intriguing insights into the atomic details of the lipid-associated structure of the major protein component of HDL, apo A-I. For the first time, an atomic resolution map is available for future studies of the molecular interactions of HDL in such biological processes as ABC1-regulated HDL assembly, LCAT activation, receptor binding, reverse lipid transport and HDL heterogeneity. Within the context of this paradigm, the current review summarizes the state of HDL research.
  • Published In

    Keywords

  • Animals, Apolipoprotein A-I, Cholesterol, Humans, Lipoproteins, Lipoproteins, HDL, Mice, Models, Molecular, Protein Conformation
  • Author List

  • Segrest JP; Li L; Anantharamaiah GM; Harvey SC; Liadaki KN; Zannis V
  • Start Page

  • 105
  • End Page

  • 115
  • Volume

  • 11
  • Issue

  • 2