Oral administration of an Apo A-I mimetic Peptide synthesized from D-amino acids dramatically reduces atherosclerosis in mice independent of plasma cholesterol.

Academic Article

Abstract

  • When apolipoprotein A-I mimetic peptides synthesized from either D- or L-amino acids were given orally to LDL receptor-null mice, only the peptide synthesized from D-amino acids was stable in the circulation and enhanced the ability of HDL to protect LDL against oxidation. The peptide synthesized from L-amino acids was rapidly degraded and excreted in the urine. When a peptide synthesized from D-amino acids (D-4F) was administered orally to LDL receptor-null mice on a Western diet, lesions decreased by 79%. When added to the drinking water of apoE-null mice, D-4F decreased lesions by approximately 75% at the lowest dose tested (0.05 mg/mL). The marked reduction in lesions occurred independent of changes in total plasma or HDL-cholesterol.
  • Published In

  • Circulation  Journal
  • Keywords

  • Administration, Oral, Amino Acids, Animals, Apolipoprotein A-I, Apolipoproteins E, Arteriosclerosis, Cells, Cultured, Chemotaxis, Cholesterol, Coculture Techniques, Female, Lipoproteins, HDL, Lipoproteins, LDL, Mice, Mice, Inbred C57BL, Mice, Knockout, Monocytes, Peptides, Receptors, LDL
  • Authorlist

  • Navab M; Anantharamaiah GM; Hama S; Garber DW; Chaddha M; Hough G; Lallone R; Fogelman AM
  • Start Page

  • 290
  • End Page

  • 292
  • Volume

  • 105
  • Issue

  • 3