The role of dysfunctional HDL in atherosclerosis.

Academic Article

Abstract

  • This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
  • Published In

    Keywords

  • Animals, Apolipoprotein A-I, Atherosclerosis, Biomimetic Materials, Cholesterol, HDL, Cholesterol, LDL, Humans, Oxidation-Reduction
  • Digital Object Identifier (doi)

    Authorlist

  • Navab M; Reddy ST; Van Lenten BJ; Anantharamaiah GM; Fogelman AM
  • Start Page

  • S145
  • End Page

  • S149
  • Volume

  • 50 Suppl