Apolipoprotein A-I mimetic peptides.

Academic Article

Abstract

  • Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits injected with peptides synthesized from all D- or all L-amino acids. The apoA-I mimetic peptide 4F increased the formation of pre-beta high-density lipoprotein, increased cholesterol efflux, and reduced lipoprotein oxidation in vitro; it increased antioxidants and vascular repair in type 1 diabetic rats; it improved vasodilation, oxidative stress, myocardial inflammation, and angiogenic potential in a mouse model of scleroderma; it reduced renal inflammation in low-density lipoprotein receptor-null mice fed a Western diet; it reduced arthritis in a rat model; it reduced adiposity, increased adiponectin levels, and improved insulin sensitivity in obese mice; and it improved high-density lipoprotein inflammatory properties in humans with coronary heart disease.
  • Published In

    Keywords

  • Animals, Anti-Inflammatory Agents, Apolipoprotein A-I, Arthritis, Atherosclerosis, Cholesterol, HDL, Diabetes Mellitus, Disease Models, Animal, Humans, Hyperlipidemias, Nephritis, Obesity, Scleroderma, Systemic
  • Author List

  • Van Lenten BJ; Wagner AC; Anantharamaiah GM; Navab M; Reddy ST; Buga GM; Fogelman AM
  • Start Page

  • 52
  • End Page

  • 57
  • Volume

  • 11
  • Issue

  • 1