Structure and function of HDL mimetics.

Academic Article

Abstract

  • HDL mimetics have been constructed from a number of peptides and proteins with varying structures, all of which bind lipids found in HDL. HDL mimetics containing a peptide or protein have been constructed with as few as 4 and as many as 243 amino acid residues. Some HDL mimetics have been constructed with lipid but without a peptide or protein component. Some HDL mimetics promote cholesterol efflux, some have been shown to have a remarkable ability to bind oxidized lipids compared to human apolipoprotein A-I (apoA-I). Many of these peptides have been shown to have antiinflammatory properties. Based on studies in a number of animal models and in early human clinical trials, HDL mimetics appear to have promise as diagnostic and therapeutic agents.
  • Keywords

  • Administration, Oral, Animals, Anti-Inflammatory Agents, Apolipoprotein A-I, Cardiovascular Diseases, Cholesterol, Humans, Hypolipidemic Agents, Lipoproteins, HDL, Molecular Mimicry, Oxidation-Reduction, Peptides, Protein Binding, Protein Conformation, Structure-Activity Relationship
  • Digital Object Identifier (doi)

    Authorlist

  • Navab M; Shechter I; Anantharamaiah GM; Reddy ST; Van Lenten BJ; Fogelman AM
  • Start Page

  • 164
  • End Page

  • 168
  • Volume

  • 30
  • Issue

  • 2