Searching for a successful HDL-based treatment strategy.

Academic Article

Abstract

  • Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using and HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I-mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful.
  • Published In

    Keywords

  • Animals, Cholesterol, HDL, Humans, Peptides, Peptidomimetics
  • Author List

  • Reddy ST; Navab M; Anantharamaiah GM; Fogelman AM
  • Start Page

  • 162
  • End Page

  • 167
  • Volume

  • 1841
  • Issue

  • 1