Searching for a Successful HDL-based Treatment Strategy.

Academic Article

Abstract

  • Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using an HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful.
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    Keywords

  • ApoA-I, Apolipoprotein A-I, CHD, Coronary heart disease, EV, FGF, FGF receptor 1, FGFR1, FPLC, Fast performance liquid chromatography, Fibroblast growth factor, HDL, HIF-1α, High density lipoprotein, Hypoxia-inducible factor-1α, LDL, LDL receptor null, LDLR(-/-), LPA, Low density lipoprotein, Lysophosphatidic acid, MCP-1, Manganese superoxide dismutase, MnSOD, Monocyte chemoattractant protein 1, SQ, SR-A, Scavenger receptor A, Subcutaneous injection, TLR, Tg6F, Toll-like receptor, Transgenic 6F tomatoes, Transgenic tomatoes constructed with an empty vector, VEGF, VEGF receptor 2, VEGFR2, Vascular endothelial growth factor, WD, Western diet, apolipoprotein A-I, apolipoprotein A-I mimetic peptide 6F, atherosclerosis, cancer, lysophosphatidic acid
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    Author List

  • Reddy ST; Navab M; Anantharamaiah GM; Fogelman AM