Apolipoprotein A-I mimetics.

Academic Article

Abstract

  • PURPOSE OF REVIEW: To summarize recent publications in the field of apolipoprotein mimetics. RECENT FINDINGS: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as potential therapeutic agents. A number of new apolipoprotein mimetics have been described recently. A major site of action of apolipoprotein mimetic peptides was found to be in the small intestine in which they decrease the levels of proinflammatory bioactive lipids. A major problem related to the use of apolipoprotein mimetic peptides is their cost, particularly those that need to be generated by solid phase synthesis with chemical addition of end-blocking groups. Novel approaches to apolipoprotein mimetic therapy have emerged recently that show promise in overcoming these barriers. SUMMARY: Despite the recent failure of therapies designed to raise HDL-cholesterol in humans, an approach to therapy using mimetics of HDL and its components continues to show promise.
  • Published In

    Keywords

  • Animals, Apolipoprotein A-I, Biomimetics, Disease, Humans, Peptidomimetics
  • Digital Object Identifier (doi)

    Authorlist

  • Reddy ST; Navab M; Anantharamaiah GM; Fogelman AM
  • Start Page

  • 304
  • End Page

  • 308
  • Volume

  • 25
  • Issue

  • 4