Diet quality and markers of endothelial function: the CARDIA study.

Academic Article

Abstract

  • BACKGROUND AND AIM: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs. METHODS AND RESULTS: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score "A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7 ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2 ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7 ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3 ng/mL)). CONCLUSION: This prospective analysis suggests that dietary patterns are associated with CAMs.
  • Keywords

  • Cellular adhesion molecules (CAMs), Cohort, Diet, Endothelial function, Epidemiology, Adolescent, Adult, Biomarkers, Cohort Studies, Coronary Artery Disease, Cross-Sectional Studies, Diet, E-Selectin, Endothelium, Vascular, Female, Humans, Intercellular Adhesion Molecule-1, Longitudinal Studies, Male, Meat, P-Selectin, Principal Component Analysis, Risk, United States, Up-Regulation, Vascular Cell Adhesion Molecule-1, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Sijtsma FPC; Meyer KA; Steffen LM; Van Horn L; Shikany JM; Odegaard AO; Gross MD; Kromhout D; Jacobs DR
  • Start Page

  • 632
  • End Page

  • 638
  • Volume

  • 24
  • Issue

  • 6