Interactions between HIV-1 and mucosal cells in the female reproductive tract.

Academic Article


  • Worldwide, the heterosexual route is the prevalent mode of HIV-1 transmission, and the female reproductive tract accounts for approximately 40% of all HIV-1 transmissions. HIV-1 infection in the female reproductive tract involves three major events: entry through the mucosal epithelium, productive infection in subepithelial mononuclear cells, and delivery to lymph nodes to initiate systemic infection. Here, we provide a focused review of the interaction between HIV-1 and mucosal epithelial cells, lymphocytes, macrophages, and dendritic cells in female genital mucosa. Increased understanding of these interactions could illuminate new approaches for interdicting HIV-1 heterosexual transmission.
  • Keywords

  • Dendritic cells, entry, epithelial cells, lymphocytes, macrophages, replication, CD4-Positive T-Lymphocytes, Dendritic Cells, Epithelial Cells, Female, Genitalia, Female, HIV Infections, HIV-1, Humans, Macrophages, Mucous Membrane
  • Digital Object Identifier (doi)

    Author List

  • Shen R; Richter HE; Smith PD
  • Start Page

  • 608
  • End Page

  • 617
  • Volume

  • 71
  • Issue

  • 6