Vaginal myeloid dendritic cells transmit founder HIV-1

Academic Article

Abstract

  • Wereport that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13+ CD11c+ DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission. © 2014, American Society for Microbiology.
  • Digital Object Identifier (doi)

    Author List

  • Shen R; Kappes JC; Smythies LE; Richter HE; Novak L; Smith PD
  • Start Page

  • 7683
  • End Page

  • 7688
  • Volume

  • 88
  • Issue

  • 13