Vaginal myeloid dendritic cells transmit founder HIV-1.

Academic Article

Abstract

  • We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.
  • Published In

    Keywords

  • Cells, Cultured, Dendritic Cells, Female, HIV Infections, HIV-1, Humans, Myeloid Cells, Receptors, CCR5, T-Lymphocytes, Vagina
  • Digital Object Identifier (doi)

    Authorlist

  • Shen R; Kappes JC; Smythies LE; Richter HE; Novak L; Smith PD
  • Start Page

  • 7683
  • End Page

  • 7688
  • Volume

  • 88
  • Issue

  • 13