Brief communication: Glomerulonephritis in patients with hepatitis C cirrhosis undergoing liver transplantation.

Academic Article

Abstract

  • BACKGROUND: Patients infected with hepatitis C virus (HCV) frequently develop renal failure after liver transplantation. OBJECTIVE: To describe renal histologic characteristics and concomitant clinical features in HCV-infected patients with end-stage cirrhosis. DESIGN: Case series. SETTING: Single-center liver transplant program in the United States. PATIENTS: 30 patients who received liver transplants for HCV-induced cirrhosis. INTERVENTION: Kidney biopsy during liver engraftment. MEASUREMENTS: Clinical data and laboratory tests of renal function within 6 months before liver transplantation. RESULTS: Twenty-five patients had immune-complex glomerulonephritis: membranoproliferative glomerulonephritis type 1 (n = 12), IgA nephropathy (n = 7), and mesangial glomerulonephritis (n = 6). Of these patients, 10 had normal serum creatinine levels, normal urinalysis results, and normal quantitative proteinuria. For 5 others, the only renal abnormality was an increased serum creatinine level. No patient had cryoglobulins in the blood or kidney. LIMITATIONS: This small observational study did not include patients with nonviral cirrhosis and did not document post-transplantation outcomes. CONCLUSIONS: Immune-complex glomerulonephritis was common in patients with end-stage HCV-induced cirrhosis and was often clinically silent. Its potential to cause renal failure after liver transplantation may be underappreciated.
  • Published In

    Keywords

  • Adult, Aged, Biopsy, Case-Control Studies, Female, Glomerulonephritis, Hepatitis C, Humans, Kidney, Liver Cirrhosis, Liver Transplantation, Male, Middle Aged, Postoperative Complications, Renal Insufficiency
  • Author List

  • McGuire BM; Julian BA; Bynon JS; Cook WJ; King SJ; Curtis JJ; Accortt NA; Eckhoff DE
  • Start Page

  • 735
  • End Page

  • 741
  • Volume

  • 144
  • Issue

  • 10