Peptide YY as a growth factor for intestinal epithelium

Academic Article

Abstract

  • Peptide YY is an abundant distal gut hormone that may play a significant role in intestinal epithelial proliferation. Gut epithelial cells express specific receptors for PYY, PYY induces proliferation in intestinal cells in vivo and in vitro, and the Y1 receptor subtype couples to mitogenic signaling pathways. In addition to proposed physiologic effects on gut mucosal maintenance, PYY proliferative effects may be hypothesized to contribute to pathophysiologic consequences of stimulated growth. © 2002 Elsevier Science Inc. All rights reserved.
  • Published In

  • Peptides  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mannon PJ
  • Start Page

  • 383
  • End Page

  • 388
  • Volume

  • 23
  • Issue

  • 2