Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4<sup>+</sup> T cells

Academic Article

Abstract

  • Inflammatory CD4+ T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII+ ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4+ T cells in the intestine and suggest that this process is dysregulated in human IBD.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Hepworth MR; Fung TC; Masur SH; Kelsen JR; McConnell FM; Dubrot J; Withers DR; Hugues S; Farrar MA; Reith W
  • Start Page

  • 1031
  • End Page

  • 1035
  • Volume

  • 348
  • Issue

  • 6238