Continuous intravenous infusion of LY171555, a potent selective D2 receptor agonist, lowers blood pressure in the conscious rat

Academic Article

Abstract

  • Cardiovascular responses to sustained infusion of quinpirole (LY171555), a dopamine (DA) D2receptor agonist, and bolus injection of quinpirole following sustained infusion were examined in conscious, unrestrained Sprague-Dawley rats to investigate the contributions of central and peripheral D2receptors to the regulation of cardiovascular function. Continuous intravenous administration of quinpirole induced a transient pressor response followed by normalization of mean arterial pressure (MAP) and, at higher doses, a decrease in MAP below control levels. Intravenous bolus injections of quinpirole administered 30 min after termination of the infusion produced dose-dependent depressor responses which were blocked by pretreatment with domperidone, a peripheral D2antagonist. The data suggest that continuous intravenous administration of quinpirole produces a transient centrally mediated pressor effect which is followed by a more sustained, peripherally mediated depressor response. © 1987 S. Karger AG, Basel.
  • Digital Object Identifier (doi)

    Author List

  • Igarashi Y; Yiu-Fai C; Wyss JM; Lindheimer MD; Oparil S
  • Start Page

  • 194
  • End Page

  • 202
  • Volume

  • 35
  • Issue

  • 4