Post-operative obesity and cachexia are risk factors for morbidity and mortality after heart transplant: multi-institutional study of post-operative weight change.

Academic Article

Abstract

  • BACKGROUND: The relationship between post-heart transplant cachexia and obesity with subsequent morbidity and mortality has not yet been reported. Therefore, the purposes of this study were to: (1) describe change in body mass index (BMI) from before transplant through 5 years after transplant; (2) identify risk factors for increased BMI at 1 year post-transplant; and (3) determine whether post-transplant BMI is associated with post-transplant morbidity and mortality. METHODS: Patients (n = 3,540) were from a non-random sample having received a heart transplant between January 1, 1996 and December 31, 2001 at 33 institutions of the Cardiac Transplant Research Database (CTRD). Patients were divided into groups using cut-offs for categories of BMI. Data were assessed according to frequencies, measures of central tendency, Pearson correlations, chi-square tests, multiple regression and stratified actuarial analyses with log-rank tests for comparisons. The level of statistical significance was set at p = 0.05. RESULTS: The number of obese patients increased significantly from immediately before heart transplant to 5 years later (17% vs 38%) (p < 0.0001). Risk factors for increased BMI at 1 year after heart transplant (explaining 56% of variance) included increased BMI at transplant, younger age, black race, non-ischemic etiology of heart disease, Status I at time of transplant and non-use of mycophenolate mofetil. Patients who were underweight or obese at 1 year post-transplant were at greater risk for rejection over time than patients who were of normal weight or overweight (p = 0.009). CONCLUSIONS: Both demographic and clinical factors are related to increased BMI at 1 year after heart transplantation. Post-transplant cachexia and obesity are risk factors for poor clinical outcomes after heart transplantation.
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    Keywords

  • Adolescent, Adult, African Continental Ancestry Group, Aged, Body Mass Index, Cachexia, Female, Graft Rejection, Heart Transplantation, Humans, Male, Middle Aged, Obesity, Postoperative Complications, Retrospective Studies, Risk Factors, Weight Gain
  • Digital Object Identifier (doi)

    Author List

  • Grady KL; Naftel D; Pamboukian SV; Frazier OH; Hauptman P; Herre J; Eisen H; Smart F; Bourge R; Cardiac Transplant Research Database Group
  • Start Page

  • 1424
  • End Page

  • 1430
  • Volume

  • 24
  • Issue

  • 9