Cardiac wound healing post-myocardial infarction: A novel method to target extracellular matrix remodeling in the left ventricle

Academic Article


  • Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice. © 2013 Springer Science+Business Media New York.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Zamilpa R; Zhang J; Chiao YA; De Castro Brás LE; Halade GV; Ma Y; Hacker SO; Lindsey ML
  • Start Page

  • 313
  • End Page

  • 324
  • Volume

  • 1037