ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.

Academic Article

Abstract

  • ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.
  • Keywords

  • Animals, Anti-Inflammatory Agents, Apolipoproteins E, Aryldialkylphosphatase, Atherosclerosis, Cell Line, Humans, Hydrogen Peroxide, Lipids, Lipoproteins, HDL, Mice, Peptides, Rabbits, Time Factors
  • Digital Object Identifier (doi)

    Authorlist

  • Datta G; Chaddha M; Handattu SP; Palgunachari MN; Nayyar G; Garber DW; Gupta H; White CR; Anantharamaiah GM
  • Start Page

  • 1
  • End Page

  • 4
  • Volume

  • 660