Rapid transition from inhaled iloprost to inhaled treprostinil in patients with pulmonary arterial hypertension.

Academic Article

Abstract

  • BACKGROUND: Inhaled treprostinil is a prostacyclin analog approved for the treatment of pulmonary arterial hypertension (PAH) that may provide a more convenient treatment option for patients receiving inhaled iloprost while maintaining the clinical benefit of inhaled prostacyclin therapy. AIMS: In this open-label safety study, 73 PAH patients were enrolled with primarily World Health Organization Class II (56%) or III (42%) symptoms. At baseline, most patients (93%) were receiving 5 μg of iloprost per dose but 38% of patients reported a dosing frequency below the labeled rate of 6-9 times daily. Patients initiated inhaled treprostinil at 3 breaths four times daily (qid) at the immediate next scheduled iloprost dose. The primary objective was to assess the safety of rapid transition from iloprost to inhaled treprostinil; clinical status and quality of life were also assessed. RESULTS: Most patients (84%) achieved the target treprostinil dose of 9 breaths qid and remained on study until transition to commercial therapy (89%). The most frequent adverse events (AEs) were cough (74%), headache (44%), and nausea (30%), and five patients prematurely discontinued study drug due to AE (n = 3), disease progression (n = 1), or death (n = 1). At week 12, the time spent on daily treatment activities was reduced compared to baseline, with a mean total savings of 1.4 h per day. Improvements were also observed at week 12 for 6-min walk distance (+16.0; P < 0.001), N-terminal pro-B-type natriuretic peptide (-74 pg/mL; P = 0.001), and the Cambridge Pulmonary Hypertension Outcome Review (all domains P < 0.001). CONCLUSIONS: Pulmonary arterial hypertension patients can be safely transitioned from inhaled iloprost to inhaled treprostinil while maintaining clinical status.
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    Keywords

  • Administration, Inhalation, Adolescent, Adult, Aged, Antihypertensive Agents, Arterial Pressure, Drug Administration Schedule, Drug Substitution, Epoprostenol, Familial Primary Pulmonary Hypertension, Female, Humans, Hypertension, Pulmonary, Iloprost, Male, Middle Aged, Prospective Studies, Pulmonary Artery, Quality of Life, Time Factors, Treatment Outcome, United States, Vasodilation, Vasodilator Agents, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Bourge RC; Tapson VF; Safdar Z; Benza RL; Channick RN; Rosenzweig EB; Shapiro S; White RJ; McSwain CS; Gotzkowsky SK
  • Start Page

  • 38
  • End Page

  • 44
  • Volume

  • 31
  • Issue

  • 1