Ionizing radiation improves survival in mice bearing intracranial high- grade gliomas injected with genetically modified herpes simplex virus

Academic Article

Abstract

  • Malignant gliomas remain incurable with current interventions. Encouraging investigational approaches include the use of genetically modified herpes simplex-1 (HSV-1) viruses as direct cytotoxic agents. Combining attenuated HSV-1 with standard therapy, human U-87 malignant glioma xenografts grown in the hind limb or intracranially in athymic nude mice were exposed to ionizing radiation, in, oculated with genetically modified HSV R3616, or received both virus and radiation. The combination of virus with fractionated ionizing radiation suggests a synergistic action and results in reduced tumor volumes and longer survivals when compared with treatment with either modality alone.
  • Published In

    Author List

  • Bradley JD; Kataoka Y; Advani S; Chung SM; Arani RB; Gillespie GY; Whitley RJ; Markert JM; Roizman B; Weichselbaum RR
  • Start Page

  • 1517
  • End Page

  • 1522
  • Volume

  • 5
  • Issue

  • 6